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Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs

Rishi R. Shah, Joanna M. Redmond, Andrei Mihut, Malini Menon, John P. Evans, John A. Murphy, Michelle A. Bartholomew, Diane M. Coe

2020Bioorganic & Medicinal Chemistry71 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryUbiquitin ligaseProteasomeJanus kinaseUbiquitinCell biologyDNA ligaseComputational biologyBiochemistryReceptorGeneBiologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments
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