Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus <i>hemB</i> Small-Colony Variant
Izabela Z. Batko, Ronald S. Flannagan, Verónica Guariglia-Oropeza, Jessica R. Sheldon, David E. Heinrichs
Abstract
SCVs rely upon hemin as a nutrient to promote siderophore utilization. Therefore, perturbation of heme biosynthesis and/or utilization represents a viable to strategy to mitigate the ability of SCV bacteria to acquire siderophore-bound iron during infection.
Topics & Concepts
SiderophoreHeminStaphylococcus aureusMicrobiologyBiologyBacteriaMutantHemeIntracellularBiochemistryGeneEnzymeGeneticsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingClostridium difficile and Clostridium perfringens research