Oxy‐/Amino‐Difluoromethylthiolation of Alkenes: Synthesis of HCF<sub>2</sub>S‐Containing Isoxazolines and Pyrazolines
Xin Chen, Yun‐Tao Shen, Zhiwei Zhao, Yu‐Jian Hou, Bo‐Xun Sun, Tai‐Gang Fan, Ya‐Min Li
Abstract
Abstract Oxy‐/amino‐difluoromethylthiolation of β,γ‐unsaturated oximes/hydrazones have been developed for construction of HCF 2 S‐containing isoxazolines and pyrazolines by employing PhSO 2 SCF 2 H as difluoromethylthiolation reagent under mild conditions. Such transformations exhibit good functional group tolerance and scalability. Possible mechanisms are proposed. magnified image
Topics & Concepts
ChemistryReagentFunctional groupCombinatorial chemistryOrganic chemistryMedicinal chemistryPolymerFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSulfur-Based Synthesis Techniques