Structure, Function and Regulation of the Plasma Membrane Calcium Pump in Health and Disease
Joachim Krebs
Abstract
In this review, I summarize the present knowledge of the structural and functional properties of the mammalian plasma membrane calcium pump (PMCA). It is outlined how the cellular expression of the different spliced isoforms of the four genes are regulated under normal and pathological conditions.
Topics & Concepts
Calcium pumpGene isoformCalciumCell biologyFunction (biology)DiseasePlasma membrane Ca2+ ATPaseMembraneChemistryBiologyBiochemistryComputational biologyGeneEnzymeMedicinePathologyOrganic chemistryATPaseIon channel regulation and functionSignaling Pathways in DiseaseIon Channels and Receptors