Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces
Rodi Abdalkader, Ken‐ichiro Kamei
Abstract
shear stress. After 24 h, while the fluid stimuli did not affect cell adhesion, they facilitated the expression of cytokeratin 19 (CK-19) intermediate filaments in cells, indicating the strengthening of the barrier function. Furthermore, morphological single-cell analysis revealed an increase in the cell body area rather than nuclei. We envision that this multi-corneal barrier-on-a-chip device will unlock new possibilities in ophthalmic drug development and will be useful for studying the effects of eye blinking shear stress on the ocular surface.
Topics & Concepts
Corneal epitheliumShear stressHuman eyeMicrofluidicsMicrofluidic chipMaterials scienceCorneaComputer scienceNanotechnologyBiologyNeuroscienceArtificial intelligenceComposite material3D Printing in Biomedical ResearchOcular Surface and Contact LensCorneal Surgery and Treatments