Cell-penetrating peptide-conjugated copper complexes for redox-mediated anticancer therapy
Quim Peña, Sergi Rodríguez-Calado, A. Jalila Simaan, Mercè Capdevila, Pau Bayón, Òscar Palacios, Júlia Lorenzo, Olga Iranzo
Abstract
CPP-conjugation promoted an enhanced anticancer activity, already detectable at short treatment times. Additionally, immunofluorescence assays show that the Cu(II) peptide-conjugate distributed throughout the cytosol without lysosomal colocalization, suggesting potential avoidance of endosomal entrapment. Overall, the systematic exploration of the tailored modifications enables us to provide further understanding on structure-activity relationships of redox-active metal-based (Cu(II)) cytotoxic complexes, which contributes to rationalize and improve the design of more efficient redox-mediated metal-based anticancer therapy.