Tendon-Inspired Nanotopographic Scaffold for Tissue Regeneration in Rotator Cuff Injuries
Woochan Kim, Ga‐Eon Kim, Mohamed Attia Abdou, Sujin Kim, Daun Kim, Sunho Park, Yang-Kyung Kim, Yonghyun Gwon, Sung-Eun Jeong, Myung‐Sun Kim, Jangho Kim
Abstract
. In particular, this study showed that the scaffolds could promote tendon regeneration along the direction of the nanotopography in the rabbit models of acute and chronic RC tears. Nanotopographic scaffold-augmented rotator cuff repair showed a more appropriate healing pattern compared to the control groups in a rabbit RC tear model. We demonstrated that the tendon ECM-like nanoscale structural cues of the tendon-inspired patch may induce the more aligned tissue regeneration of the underlying tissues including tendon-to-bone interface.
Topics & Concepts
TendonRegeneration (biology)Rotator cuffNanotopographyScaffoldExtracellular matrixTearsMedicineBiomedical engineeringWound healingAnatomyCell biologySurgeryBiologyShoulder Injury and TreatmentNerve Injury and RehabilitationTendon Structure and Treatment