2,5-hexanedione induces NLRP3 inflammasome activation and neurotoxicity through NADPH oxidase-dependent pathway
Ruixue Huang, Liyan Hou, Xingyue Zhai, Zhengzheng Ruan, Wei Sun, Dongdong Zhang, Xiulan Zhao, Qingshan Wang
Topics & Concepts
InflammasomeNADPH oxidaseApocyninNeurotoxicityMicrogliaChemistryCell biologyNeuroinflammationMAPK/ERK pathwayCaspase 1Signal transductionReactive oxygen speciesInflammationBiochemistryBiologyImmunologyReceptorToxicityOrganic chemistryInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideNeutrophil, Myeloperoxidase and Oxidative Mechanisms