HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues
G.J. Lockbaum, L.N. Rusere, M. Henes, K. Kosovrasti, Desaboini Nageswara Rao, E. Spielvogel, Sook-Kyung Lee, E.A. Nalivaika, Ronald Swanstrom, Neşe Kurt Yılmaz, Celia A. Schiffer, Akbar Ali
Topics & Concepts
PhosphonateChemistryMoietyDarunavirProteasePotencyStereochemistryHIV-1 proteaseProtease inhibitor (pharmacology)BiochemistryHuman immunodeficiency virus (HIV)Combinatorial chemistryIn vitroEnzymeVirologyAntiretroviral therapyBiologyViral loadHIV/AIDS drug development and treatmentHIV Research and TreatmentPneumocystis jirovecii pneumonia detection and treatment