Bond energy enabled amine distinguishing strategy: chemo-, regioselective 1,3-diamination of (trifluoromethyl)alkenes with different amines by two C(sp<sup>3</sup>)–F bond cleavages
Hao Zeng, Hengyuan Li, Chengxi Li, Huanfeng Jiang, Chuanle Zhu
Abstract
ipso -Defluorinative amination-triggered 1,3-diamination of (trifluoromethyl)alkenes with different amines affords various monofluoroalkenylated acyclic 1,3-diamines in high yields with excellent Z / E selectivity.
Topics & Concepts
ChemistryAminationTrifluoromethylRegioselectivityAmine gas treatingSelectivityMedicinal chemistryOrganic chemistryCombinatorial chemistryCatalysisAlkylFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions