Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease
Song‐Young Park, Elizabeth J. Pekas, Cody Anderson, Tyler N. Kambis, Paras K. Mishra, Molly Schieber, TeSean K. Wooden, Jonathan R. Thompson, Kyung‐Soo Kim, Iraklis I. Pipinos
Abstract
Ex vivo skeletal muscle arteriole endothelial function is impaired in claudicating patients with PAD, and this is associated with attenuated skeletal muscle mitochondrial respiration. In vivo skeletal muscle oxygen delivery and utilization capacity is compromised in PAD, and this may be due to microcirculatory and mitochondrial dysfunction. These results suggest that targeting skeletal muscle arteriole function may lead to improvements in skeletal muscle mitochondrial respiration and oxygen delivery and utilization capacity in claudicating patients with PAD.
Topics & Concepts
Skeletal muscleArterioleRespirationOxygen deliveryMitochondrionIn vivoInternal medicineMedicinePeripheralEx vivoEndocrinologyMicrocirculationOxygenCardiologyAnatomyChemistryBiologyBiochemistryBiotechnologyOrganic chemistryPeripheral Artery Disease ManagementDialysis and Renal Disease ManagementCardiovascular Health and Disease Prevention