Cell-based Noninvasive Prenatal Testing (cbNIPT)—A Review on the Current Developments and Future Prospects
Mohamad Ali Maktabi, Liesbeth Vossaert, Ignatia B. Van den Veyver
Abstract
Considering the diagnostic limitations of cfDNA-based noninvasive prenatal testing (NIPT), scientists have long been interested in isolating and analyzing rare intact fetal and trophoblast cells from maternal blood or endocervical samples to diagnose fetal genetic conditions. These cells may be scarce and difficult to isolate, but they are a direct source of pure fetal genetic material. In this review, we summarize the history of cell-based NIPT, present an updated review on its current developments, evaluate its genetic diagnostic potential, and discuss its future prospects for clinical use.
Topics & Concepts
MedicineGenetic testingPrenatal diagnosisDiagnostic testFetoscopyFetusGenetic counselingIntensive care medicineObstetricsPregnancyPediatricsInternal medicineGeneticsBiologyPrenatal Screening and DiagnosticsFetal and Pediatric Neurological DisordersParvovirus B19 Infection Studies