Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
Bernhard Retzl, Roland Hellinger, Edin Muratspahić, Meri Emili F. Pinto, Vanderlan S. Bolzani, Christian W. Gruber
Abstract
trypsin inhibitor-like peptides. According to their phylogenetic distribution they appear to be common in several plant families. Therefore, the presented approach and our results may help to discover and classify other plant-derived cystine knot peptides, a class of plant molecules that play important functions in plant physiology and are currently being explored as lead molecules and scaffolds in drug development.
Topics & Concepts
OligopeptidaseProteaseBiochemistryTrypsinPeptideBiologyTrypsin inhibitorProtease inhibitor (pharmacology)SubfamilyPeptidomimeticPeptide sequenceAmino acidChemistryComputational biologyEnzymeGeneticsGeneAntiretroviral therapyVirusViral loadBiochemical and Structural CharacterizationAntimicrobial Peptides and ActivitiesPhytochemical compounds biological activities