IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome
Slimane Allali, Mariane de Montalembert, Rachel Rignault‐Bricard, Mélissa Taylor, Joséphine Brice, Valentine Brousse, Jean-Marc Talbot, Florence Moulin, Claire Heilbronner, Olivier Hermine, Thiago Trovati Maciel
Abstract
Key Points Sputum interleukin-6 (IL-6) level is high during acute chest syndrome (ACS) in pediatric sickle cell disease, supporting anti–IL-6 trials. Sputum IL-8, CCL2, and CCL3 levels are also high during ACS, possibly contributing to recruitment of inflammatory cells in the lungs.
Topics & Concepts
Acute chest syndromeMedicineSputumDiseaseInternal medicineSickle cell anemiaImmunologyCardiologyPathologyTuberculosisHemoglobinopathies and Related DisordersHematological disorders and diagnosticsIron Metabolism and Disorders