I<sub>2</sub>-promoted formal [3 + 1 + 1 + 1] cyclization to construct 5-cyano-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine using malononitrile as a C1 synthon
Zhi‐Cheng Yu, Xi Shen, You Zhou, Xiang‐Long Chen, Li‐Sheng Wang, Yan‐Dong Wu, Haoke Zhang, Kai‐Lu Zheng, An‐Xin Wu
Abstract
A novel [3 + 1 + 1 + 1] cyclization reaction for the synthesis of compounds based on a 5-cyano-1 H -pyrazolo[3,4- b ]pyridine skeleton from aryl methyl ketones, malononitrile and 5-aminopyrazoles has been established.
Topics & Concepts
MalononitrileSynthonChemistryPyridineMedicinal chemistryFormal synthesisArylStereochemistryCombinatorial chemistryOrganic chemistryCatalysisAlkylSynthesis and Reactivity of HeterocyclesSynthesis and Biological EvaluationMulticomponent Synthesis of Heterocycles