Neurotrophic factor-α1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice
Fang-Cheng Fan, Liming Liu, Mei Guo, Yang Du, Yuewen Chen, Y. Peng Loh, Yong Cheng
Abstract
NF-α1/CPE is a critical regulator of AD pathogenesis, offering promising therapeutic potential for reducing amyloid beta deposition and toxicity in AD.
Topics & Concepts
PathogenesisNeurotrophic factorsDiseaseBrain-derived neurotrophic factorNeuroscienceMedicineNeurotrophinAlzheimer's diseasePathologyInternal medicineBiologyReceptorApelin-related biomedical researchNerve injury and regenerationEndoplasmic Reticulum Stress and Disease