3D bioprintable methacrylated carrageenan/sodium alginate dual network hydrogel for vascular tissue engineering scaffolding
Anduo Zhou, Yasong Hu, Chongshuai Chen, Heyi Mao, Lei Wang, Shanfeng Zhang, Xia Huang
Abstract
3D printing technology has significant advantages in the processing field of vascular tissue engineering. We have developed KCMA/SA hydrogels based on methacrylated carrageenan (KCMA) and sodium alginate (SA), which have low viscosity and shear thinning properties and can be used for 3D printing. The physicochemical double cross-linked network structure leads to good mechanical properties. The composite hydrogels maintain the liquid crystallinity of KC, which causes the HUVECs to align. The KCMA/SA gel filaments printed by the 3D extrusion printing system formed a connected microstructure. These characteristics all indicate the potential of KCMA/SAs in the field of tubular tissue regeneration.