Pt(<scp>iv</scp>) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?
Alvaro Lopez‐Sanchez, Hélène Bertrand
Abstract
Oxaliplatin( iv ) prodrugs, classified by the role of their axial ligands, are presented with a focus on their in vitro stability and activity in in vivo models, illustrating their potential to address current Pt-based chemotherapy's main limitations.
Topics & Concepts
OxaliplatinProdrugIn vivoIn vitroChemistryScaffoldChemotherapyPharmacologyCancer researchMedicineBiochemistryCancerBiomedical engineeringBiologyInternal medicineColorectal cancerBiotechnologyMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsDNA and Nucleic Acid Chemistry