Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor
Hayden Selvadurai, Erika Luis, Kinjal Desai, Xiaoyang Lan, Maria Vladoiu, Owen Whitley, Ciaran Galvin, Robert J. Vanner, Lilian Lee, Heather Whetstone, Michelle Kushida, Tomasz J. Nowakowski, Phedias Diamandis, Cynthia Hawkins, Gary D. Bader, Arnold R. Kriegstein, Michael D. Taylor, Peter B. Dirks
Abstract
tumor cells. Critically, constitutive activation of the SHH pathway leads to their aberrant persistence in the EGL and rapid tumor onset. We propose that failure to eliminate this rare but potent developmental population is the tumor initiation mechanism in SHH-subgroup MB.
Topics & Concepts
Sonic hedgehogMedulloblastomaSOX2BiologyPrecursor cellPopulationCancer researchCell biologyNeuroscienceEmbryonic stem cellGeneticsCellMedicineSignal transductionGeneEnvironmental healthHedgehog Signaling Pathway StudiesEpigenetics and DNA MethylationSingle-cell and spatial transcriptomics