Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4,4’-(Arylmethylene)bis(1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 M<sup>pro</sup>
Anamika Gupta, Safia Iqbal, Roohi Roohi, Mohd Kamil Hussain, Mohd. Rehan Zaheer, Krapa Shankar
Abstract
(-8.3 and -8.8 Kcal/mole, respectively) than few reported drugs such as ritonavir, remdesivir, ribacvirin, favipiravir, hydroxychloroquine, chloroquine, and olsaltamivir. Hence, it reveals the possibility of these compounds to be used as effective COVID-19 inhibitors.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)In vitroDocking (animal)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Chemistry2019-20 coronavirus outbreakPharmacologyComputational biologyCombinatorial chemistryBiologyVirologyMedicineBiochemistryInternal medicineInfectious disease (medical specialty)DiseaseOutbreakNursingMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySulfur-Based Synthesis Techniques