Peptides from Antarctic krill (<i>Euphausia superba</i>) ameliorate acute liver injury in mice induced by carbon tetrachloride <i>via</i> activating the Nrf2/HO-1 pathway
Meng Wang, Lei Zhang, Hao Yue, Weizhen Cai, Haowen Yin, Yingying Tian, Pingsha Dong, Jingfeng Wang
Abstract
-induced liver injury, which was identified by the decrease in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), alleviation of hepatocyte necrosis, and inhibition of the levels of the pro-inflammatory factors TNF-α and IL-1β compared to those for silymarin. AKP pretreatment also enhanced the redox balance by reducing the concentrations of MDA and 8-iso-PG and increasing the activities of SOD, GSH and GSH-PX in the liver of mice. In addition, AKP upregulated oxidative stress-related mRNA expressions of Nrf2, Keap1, HO-1, and NQO1 and further activated the protein expression on the Nrf2/HO-1 singling pathway. In summary, AKP might be a promising hepatoprotective nutraceutical against ALI and its underlying mechanisms are associated with activation of the Nrf2/HO-1 pathway.