Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
S.Z. Kiss, Neil MacKinnon, Jan G. Korvink
Abstract
Nuclear magnetic resonance at low field strength is an insensitive spectroscopic technique, precluding portable applications with small sample volumes, such as needed for biomarker detection in body fluids. Here we report a compact double resonant chip stack system that implements in situ dynamic nuclear polarisation of a 130 nL sample volume, achieving signal enhancements of up to - 60 w.r.t. the thermal equilibrium level at a microwave power level of 0.5 W. This work overcomes instrumental barriers to the use of NMR detection for point-of-care applications.
Topics & Concepts
MicrofluidicsSIGNAL (programming language)Nuclear Overhauser effectNuclear magnetic resonanceChipMaterials scienceNuclear magnetic resonance spectroscopyChemistryComputer scienceNanotechnologyPhysicsTelecommunicationsProgramming languageAdvanced MRI Techniques and ApplicationsNMR spectroscopy and applicationsAdvanced NMR Techniques and Applications