Three-Component Synthesis of Isoquinolone Derivatives via Rh(III)-Catalyzed C–H Activation and Tandem Annulation
Zhenke Yang, Jidan Liu, Yuting Li, Jiawen Ding, Liyao Zheng, Zhao‐Qing Liu
Abstract
A one-pot three-component synthesis of multifunctionalized isoquinolones from 2-oxazolines, iodonium ylides, and carboxylic acids via Rh(III)-catalyzed oxazolinyl-directed C-H activation and tandem annulation under redox-neutral conditions has been developed. This catalytic system is characterized by readily available starting materials, a wide tolerance of functional groups, a short reaction time, and high yields. The synthetic utility of the cascade reaction was further demonstrated by a gram-scale synthesis and derivatization of the obtained products.
Topics & Concepts
AnnulationTandemCatalysisChemistryCascade reactionDerivatizationCombinatorial chemistryReaction conditionsCascadeOrganic chemistryChromatographyComposite materialHigh-performance liquid chromatographyMaterials scienceCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions