The human placenta shapes the phenotype of decidual macrophages
Sigrid Vondra, Anna-Lena Höbler, Andreas Ian Lackner, Johanna Raffetseder, Zala Nikita Mihalič, Andrea Vogel, Leila Saleh, Victoria Kunihs, Peter Haslinger, Markus Wahrmann, H Husslein, Raimund Oberle, Julia Kargl, Sandra Haider, Paulina A. Latos, Gernot Schabbauer, Martin Knöfler, Jan Ernerudh, Jürgen Pollheimer
Abstract
(Cell Reports 42, 111977; January 31, 2023) In the originally published version of this article, Figure 1A contained two identical immunofluorescence (IF) images. The IF picture showing vWF (magenta) and HLA-G (green) was erroneously repeated at the position of the image marked α-SMA (magenta) and panKeratin (green). The corrected version of Figure 1A, which includes the correct IF picture for α-SMA (magenta) and panKeratin (green), now appears in the article online and is shown below alongside the original version of the figure. This change does not affect the conclusions of the study. The authors sincerely apologize for any confusion this error may have caused. The human placenta shapes the phenotype of decidual macrophagesVondra et al.Cell ReportsJanuary 10, 2023In BriefVondra et al. report the accumulation of CD163+CD206+CD11chiHLA-DRlo macrophages termed decidua basalis-associated macrophages (decBAMs). decBAMs proliferate, secrete pregnancy-sustaining factors, and induce Tregs but show diminished phagocytosis and T cell activation efficiency. The secretome of placenta-derived trophoblasts partly induces this phenotype, suggesting that placentation co-regulates macrophage polarization during human pregnancy. Full-Text PDF Open Access