Insertion of Small Flexible Linkers as a Useful Scaffold Hopping Tool in Agrochemistry
Clemens Lamberth
Abstract
Inserting small flexible linkers of only one- to three-atom chain lengths into a molecular backbone is an important scaffold hopping manipulation. Analogues derived from biologically active compounds through the utilization of such a strategy are often similar in shape and physicochemical properties and, therefore, likely to exhibit similar potency. This review will demonstrate how the elongation with oxygen, amino, methylene, ethylene, vinyl, ethynyl, and CH2O bridges led to the discovery of highly active agrochemicals.
Topics & Concepts
ScaffoldMethyleneChemistryEthyleneBiological activityCombinatorial chemistryElongationPotencyStereochemistryBiophysicsMaterials scienceIn vitroOrganic chemistryBiochemistryComputer scienceBiologyUltimate tensile strengthCatalysisDatabaseMetallurgyPlant tissue culture and regenerationEnzyme Catalysis and ImmobilizationFungal Plant Pathogen Control