A K<sup>+</sup>-selective channel with a record-high K<sup>+</sup>/Na<sup>+</sup>selectivity of 20.1
Jin Lei, Chang Q. Sun, Zhong-Yan Li, Jie Shen, Huaqiang Zeng
Abstract
For compounds each containing a phenylalanine moiety with its two ends amidated to have a 15-crown-5 group and an alkyl chain, a simple tuning of the alkyl chain length delivered a K + -selective channel with a record-high K + /Na + selectivity of 20.1.
Topics & Concepts
SelectivityAlkylMoietyChemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisMolecular Sensors and Ion DetectionIon channel regulation and functionCrystallography and molecular interactions