CsrA Coordinates Compatible Solute Synthesis in Acinetobacter baumannii and Facilitates Growth in Human Urine
Josephine Joy Hubloher, Kim Schabacker, Volker Müller, Beate Averhoff
Abstract
The opportunistic human pathogen Acinetobacter baumannii has become one of the leading causes of nosocomial infections around the world due to the increasing prevalence of multidrug-resistant strains and their optimal adaptation to clinical environments and the human host. Recently, it was found that CsrA, a global mRNA binding posttranscriptional regulator, plays a role in osmotic stress adaptation, virulence, and growth on amino acids of A. baumannii AB09-003 and 17961.
Topics & Concepts
Acinetobacter baumanniiMutantStrain (injury)AcinetobacterBiologyBacteriaMicrobiologyHuman pathogenEnterobacteriaceaeNeisseriaceaeOsmotic concentrationAmino acidOsmotic shockGeneAdaptation (eye)PathogenReversionGeneticsCarbon sourceMetabolismWild typeRegulatorBiochemistryResponse regulatorMutationAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology