Tumor cell exosome circ-0023919 promotes EMT through the miR-197-5p/ICAM5 axis and enhances the drug resistance of colorectal cancer to 5-fu
Jingjing Zhang, Yuanxiang Wu, Yaping Wang, Huihui Zeng
Topics & Concepts
BiologyMicrovesiclesDrug resistanceExosomeCancer researchColorectal cancerCell cultureCellCell sortingCancerDrugIn vitroCancer cellRNA interferenceCell biologyDrug developmentTranscriptomemicroRNAWestern blotDoxycyclineMicroarray analysis techniquesKRASSmall interfering RNAGene knockdownMechanism (biology)Tumor progressionCell growthSanger sequencingCircular RNAs in diseasesExtracellular vesicles in diseaseMicroRNA in disease regulation