Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
Lingling Zhu, Yujia Yuan, Longhui Yuan, Lan Li, Fei Liu, Jingping Liu, Younan Chen, Yanrong Lu, Jingqiu Cheng
Abstract
: Our data suggest that trehalose treatment preserves mitochondria function via activation of TFEB-mediated autophagy and attenuates cisplatin-induced kidney injury.
Topics & Concepts
AutophagyTFEBTrehaloseCisplatinCell biologyMitochondrionReactive oxygen speciesProgrammed cell deathNephrotoxicityChemistryCancer researchApoptosisAcute kidney injuryKidneyPharmacologyBiologyMedicineBiochemistryInternal medicineEndocrinologyChemotherapyChemotherapy-induced organ toxicity mitigationAutophagy in Disease and TherapyBiomedical Research and Pathophysiology