Ferroptosis resistance mediated by exosomal release of iron
Caitlin W. Brown, Arthur M. Mercurio
Abstract
Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.
Topics & Concepts
IntracellularMicrovesiclesCell biologyProgrammed cell deathExosomeGPX4CellCancer cellCancer researchBiologyChemistryCancerApoptosisBiochemistryGeneticsGenemicroRNAGlutathioneEnzymeGlutathione peroxidaseFerroptosis and cancer prognosisExtracellular vesicles in diseaseCaveolin-1 and cellular processes