Thieno[2,3-<i>b</i>]thiophene Derivatives as Potential EGFR<sup>WT</sup> and EGFRT<sup>790M</sup> Inhibitors with Antioxidant Activities: Microwave-Assisted Synthesis and Quantitative In Vitro and In Silico Studies
Sanaa A. Ahmed, Moumen S. Kamel, Moustafa O. Aboelez, Xiang Ma, Ahmed A. Al‐Karmalawy, Sayed A. S. Mousa, E. Kh. Shokr, H. Abdel‐Ghany, Amany Belal, Mohamed A. El Hamd, Zafer Saad Al Shehri, Mahmoud Abd El Aleem Ali Ali El‐Remaily
Abstract
) to study their mechanism of action as EGFR inhibitors. In silico absorption, distribution, metabolism, excretion, and toxicity tests were also performed to explain the physicochemical features of the examined derivatives.
Topics & Concepts
ErlotinibChemistryGefitinibCytotoxicityEpidermal growth factor receptorA549 cellMTT assayThiopheneEGFR inhibitorsDocking (animal)StereochemistryIn silicoIC50In vitroCombinatorial chemistryBiochemistryReceptorOrganic chemistryGeneNursingMedicineSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsMulticomponent Synthesis of Heterocycles