Photoinduced Palladium-Catalyzed Intermolecular Radical Cascade Cyclization of <i>N</i>-Arylacrylamides with Unactivated Alkyl Bromides
Juan Du, Xing Wang, Hongling Wang, Jinhu Wei, Xuan Huang, Jun Song, Junmin Zhang
Abstract
A mild visible-light-induced Pd-catalyzed intermolecular radical cascade reaction of N-arylacrylamides with unactivated alkyl bromides is disclosed. Photoexcited Pd complexes transfer a single electron in this protocol, and hybrid alkyl Pd-radical species are involved as the key reaction intermediates. Sophisticated bioactive oxindole derivatives bearing various substituents and substitution patterns can be efficiently afforded through this approach.
Topics & Concepts
ChemistryIntermolecular forceCatalysisAlkylPalladiumOxindoleCascadePhotochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryMoleculeChromatographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques