Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides <i>via</i> a supramolecular approach using a high-speed vibration milling technique
Shogo Kawamura, Riku Kawasaki, Shodai Hino, Keita Yamana, Masafumi Okuno, Takuro Eto, Atsushi Ikeda
Abstract
a high-speed vibrational milling method. Poly-l-lysine and poly-γ-glutamic acid, which are polypeptides, were able to prepare more highly concentrated water-dispersible complexes of hydrophobic compounds, including fullerenes, organic dyes, and porphyrin derivatives, than conventional water solubilizers, such as cyclodextrins and pullulan. In addition, the polypeptide systems endowed the complexes with long-term stability and resistance against thermal stress, which is advantageous for industrial applications. Furthermore, complexes of polypeptides and porphyrin derivatives showed a photodynamic activity against cancer cells, and the current system improved the dispersibility and storability of guest molecules without compromising their functionality.