Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice
Yuan Wang, Shan Zhu, Wen Wei, Yi Tu, Chuang Chen, Jun‐Long Song, Juanjuan Li, Changhua Wang, Zhiliang Xu, Shengrong Sun
Abstract
. Furthermore, the mRNA expression of both aging markers and apoptosis-related markers was markedly inhibited by IL-6 KO. Our results suggest that aging can be significantly reversed by IL-6 KO and that the mechanisms of this effect are related to alleviation of Mø1/Mø2 imbalance and protection against apoptosis in cardiomyocytes.
Topics & Concepts
Knockout mouseMacrophageMedicineInterleukin 1βInterleukinImmunologyInternal medicineEndocrinologyCytokineBiologyGeneticsReceptorIn vitroCardiac Fibrosis and RemodelingGDF15 and Related BiomarkersSignaling Pathways in Disease