Site-Selective Nitration of Arene via Hypervalent Iodine-Mediated C–H Functionalization
Ziyang Zhang, Wenjing Bao, Guangxing Gu, Zhenjiang Liu, Yanchuan Zhao
Abstract
We developed a novel nitration method using hypervalent iodine for site-selective C-H functionalization. This technique efficiently synthesizes nitroarenes with high regioselectivity and is scalable, enhancing the late-stage modification of bioactive pharmaceuticals.
Topics & Concepts
Hypervalent moleculeNitrationChemistrySurface modificationIodineCombinatorial chemistryOrganic chemistryPhysical chemistryOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions