Taxifolin retards the <scp>d</scp>-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice
Xinglong Liu, Yingchun Zhao, Hongyan Zhu, Ming‐Fang Wu, Yinan Zheng, Min Yang, Zhiqiang Cheng, Chuanbo Ding, Wencong Liu
Abstract
. In conclusion, the results of this study demonstrated that TAX alleviated oxidative stress injury in mice aged by D-Gal and also confirmed that TAX improved the aging process by regulating intestinal microbes, which provides the possibility of prevention and treatment for aging and metabolic disorders through the potential food health factors.
Topics & Concepts
Oxidative stressAntioxidantPI3K/AKT/mTOR pathwayReactive oxygen speciesPharmacologyEndocrinologyInternal medicineBiologyMedicineSignal transductionBiochemistryAntioxidants, Aging, Portulaca oleraceaMedicinal Plants and Bioactive CompoundsBiochemical effects in animals