Revelation of potential bioactive water-soluble Boc-<scp>l</scp>-valine and imidazole appended metal complexes {M = Co(<scp>ii</scp>), Cu(<scp>ii</scp>) & Zn(<scp>ii</scp>)}: synthesis, characterization, ct-DNA binding, pBR322 cleavage, SOD mimetic, and cytotoxicity studies
Suffora Akhter, Salman Khursheed, Farukh Arjmand, Sartaj Tabassum
Abstract
value of 2.08 μM and (vi) a good and selective cytotoxicity profile against chemo-resistant MCF-7 and MDA-MB-231 cancer cell lines by complex 1. Molecular docking studies complemented the spectroscopic results and confirmed the electrostatic interaction of complexes in the groove region of DNA.
Topics & Concepts
ChemistryStereochemistryImidazoleCrystallographyProton NMRMetal complexes synthesis and propertiesCrystal structures of chemical compoundsMagnetism in coordination complexes