Persistent blood DNA methylation changes one year after SARS-CoV-2 infection
Joseph Balnis, Andy Madrid, Kirk J. Hogan, Lisa A. Drake, Anish Adhikari, Rachel Vancavage, Harold A. Singer, Reid S. Alisch, Ariel Jaitovich
Abstract
We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fifteen participants previously hospitalized for SARS-CoV-2 infection were epityped one year after discharge. Of the 1505 acute illness-induced differentially methylated regions (DMRs) previously identified, we found 71 regions with persisted differentially methylated, with an average of 7 serial CpG positions per DMR. Sixty-four DMRs persisted hypermethylated, and 7 DMR persisted hypomethylated. These data are the first reported evidence that DNA methylation changes in circulating leukocytes endure long after recovery from acute illness.