Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice
Ya-Ling Chen, Tong Wang, Fuxiang Liang, Jia Han, Zhiling Lou, Yifan Yu, Jinsheng Li, Tianwei Zhan, Yuqing Gu, Lingjun Dong, Bo Jiang, Weiping Zhang, Zixiang Wu, Yun‐Bi Lu
Abstract
NAMPT prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice. Targeting the NAMPT of monocytes/macrophages is a promising strategy for treating pulmonary fibrosis.
Topics & Concepts
BleomycinPulmonary fibrosisMacrophage polarizationNicotinamide phosphoribosyltransferaseIdiopathic pulmonary fibrosisFibrosisCancer researchMacrophageMedicineChemistryImmunologyLungPathologyInternal medicineBiochemistryNAD+ kinaseEnzymeIn vitroChemotherapyInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisPI3K/AKT/mTOR signaling in cancerLung Cancer Research Studies