Palladium‐Catalyzed Asymmetric Decarboxylative Addition of β‐Keto Acids to Heteroatom‐Substituted Allenes
Dong‐Jin Jang, Sukhyun Lee, Juyeol Lee, Dohyun Moon, Young Ho Rhee
Abstract
The Pd-catalyzed asymmetric addition reaction of β-keto acids to heteroatom-substituted allene is reported. This reaction generates β-substituted ketones in an asymmetric manner through a branch-selective decarboxylative allylation pathway. The reaction accommodates various alkoxyallenes as well as amidoallenes.
Topics & Concepts
AlleneHeteroatomChemistryPalladiumCatalysisEnantioselective synthesisDecarboxylationOrganic chemistryMedicinal chemistryRing (chemistry)Catalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisCatalytic Alkyne Reactions