A simulation of skin mitochondrial P<scp>o</scp><sub>2</sub> in circulatory shock
Bashar N. Hilderink, Reinier F. Crane, Meryem Baysan, M. Sesmu Arbous, Bas van den Bogaard, Egbert G. Mik, Can İnce, Janesh Pillay, Nicole P. Juffermans
Abstract
This is the first paper to simulate mitochondrial oxygen tension in skin in circulatory shock. The relationships of mitoPo 2 with parameters of (microcirculatory) oxygen delivery aid in the understanding of noninvasive bedside measurement of mitoPo 2 values and show that mitochondrial oxygen tension is two orders of magnitude higher than classically assumed. The model can be used to enhance clinical trial design investigating mitoPo 2 as a resuscitation target in circulatory shock.
Topics & Concepts
Blood flowMicrocirculationCirculatory systemPerfusionShock (circulatory)OxygenHematocritOxygenatorHypoxia (environmental)Oxygen tensionChemistryCardiologyBiophysicsMedicineInternal medicineBiologyCardiopulmonary bypassOrganic chemistryHeart Rate Variability and Autonomic ControlCardiac Arrest and ResuscitationRespiratory Support and Mechanisms