RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding
Elsa Zacco, Laura Broglia, Misuzu Kurihara, Michele Monti, Stefano Gustincich, Annalisa Pastore, Kathrin Plath, Shinichi Nagakawa, Andrea Cerase, Natalia Sánchez de Groot, Gian Gaetano Tartaglia
Abstract
, in the formation of phase-separated assemblies and their influence on the cellular landscape, we emphasize their crucial role in cellular organization and function. By elucidating the chemical underpinnings of RNA-mediated molecular crowding, investigating the role of modifications, structures, and composition of RNA granules, and exploring both physiological and aberrant phase separation phenomena, this Review provides a multifaceted understanding of the intriguing world of RNA-mediated biological condensates.
Topics & Concepts
Macromolecular crowdingRNACrowdingChemistryComputational biologyFunction (biology)NanotechnologyCell biologyBiologyNeuroscienceMacromoleculeBiochemistryGeneMaterials scienceRNA Research and SplicingRNA modifications and cancerRNA and protein synthesis mechanisms