The Wnt pathway regulator expression levels and their relationship to bone metabolism in thoracolumbar osteoporotic vertebral compression fracture patients.
Xuefeng Ma, Zhu Xiaoqi, Xu He, Xiaobo Yi, Anmin Jin
Abstract
OBJECTIVE: To investigate of the Wnt pathway serum regulator expression levels and their relationship with bone metabolism (BM) in thoracolumbar osteoporotic vertebral compression fracture (OVCF) patients. METHODS: In this study, 40 healthy controls (group A), 33 osteoporotic patients (group B), and 47 thoracolumbar OVCF patients (group C) were recruited as the study cohort during the same period. The Wnt pathway serum regulator levels, bone density, BM-related inflammatory cytokines, bone formation markers, and bone resorption markers were compared among the three groups, and the correlation between the Wnt pathway serum regulators and BM was analyzed. RESULTS: < 0.05). CONCLUSION: Patients with thoracolumbar OVCF have abnormal Wnt pathway serum regulator expression levels, low bone density, and abnormal BM, and the patients' Wnt/β-catenin and DKK-1 levels are closely related to BM, so they may be potential targets for the prevention and treatment of metabolic bone diseases.