A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo
Yin-Ru Li, Fangfang Liu, Wenbo Liu, Yifan Zhang, Xin-Yi Tian, Xiang-Jing Fu, Yan Xu, Jian Song, Sai‐Yang Zhang
Topics & Concepts
HDAC1Histone deacetylaseTubulinChemistryIn vivoEpigeneticsAcetylationHistoneMicrotubuleCell cycle checkpointCancer researchHistone deacetylase inhibitorCell cycleCell biologyBiochemistryBiologyApoptosisGeneGeneticsHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsCatalytic C–H Functionalization Methods