Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)
Patrik Olekšák, Eugenie Nepovimová, Žofia Chrienová, Kamil Musílek, Jiří Patočka, Kamil Kuča
Topics & Concepts
PI3K/AKT/mTOR pathwaymTORC2mTORC1Mechanistic target of rapamycinRPTORKinaseChemistryDiscovery and development of mTOR inhibitorsPharmacologyCancer researchSignal transductionBiologyBiochemistryPI3K/AKT/mTOR signaling in cancerCRISPR and Genetic EngineeringMast cells and histamine