Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1
Songwei Lv, Jingfang Wang, Rongrong You, Suyu Liu, Yujie Ding, Roja Hadianamrei, Mhd Anas Tomeh, Fang Pan, Zhiqiang Cai, Xiubo Zhao
Abstract
efficiency of this peptide. The peptides were more effective against Gram-negative bacteria and no AMR was developed against them in the bacteria even after 25 generations. The results from this study can provide a better understanding of the structural features required for strong antibacterial activity and selectivity, and serve as a guide for the future rational design of AMPs.
Topics & Concepts
Antimicrobial peptidesPeptideAntimicrobialAntibacterial activityChemistryBacteriaAmino acidBiochemistryAntibioticsPeptide sequenceCationic polymerizationAntibacterial peptideIn vivoIn vitroAntibacterial agentCombinatorial chemistryBiologyOrganic chemistryBiotechnologyGeneGeneticsAntimicrobial Peptides and ActivitiesProtein Hydrolysis and Bioactive PeptidesBiochemical and Structural Characterization