Copper-Catalyzed Annulation Reaction of Alkenes and <i>N</i>-Alkyl(aryl)-1-(methylthio)-2-nitroethenamine: an Approach for the Synthesis of Isoxazole Derivatives
Zhengbing Pan, Kaimin Mao, Guang‐Zhou Zhu, Chang Wang, Jinpeng Zhang, Liangce Rong
Abstract
A copper-catalyzed annulation reaction to access a variety of isoxazoles from alkenes and oxazete in situ generated from N-alkyl(aryl)-1-(methylthio)-2-nitroethenamine was reported. A plausible mechanism underlying the formation of the product was proposed, which represented a new approach for the construction of isoxazolines. This reaction was capable of tolerating alkenes bearing various substituents, which showed a relatively broad substrate scope with good functional group compatibility.
Topics & Concepts
ChemistryAnnulationArylAlkylIsoxazoleCatalysisOrganic chemistryFunctional groupMedicinal chemistryCombinatorial chemistryCopperPolymerSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques