Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma
Matthew L. Hedberg, Corbett T. Berry, Ata S. Moshiri, Yan Xiang, Christopher Yeh, Cem Attilasoy, Brian C. Capell, John T. Seykora
Abstract
Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.
Topics & Concepts
Skin cancerBasal cellBasal cell carcinomaIncidence (geometry)PathogenesisDermatologyCancerMedicineMelanomaCancer researchOncologySquamous cell cancerBioinformaticsPathologyInternal medicineBiologyPhysicsOpticsNonmelanoma Skin Cancer StudiesCancer-related Molecular PathwaysMelanoma and MAPK Pathways