The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction
Wei Gong, Lingling Lu, Yu Zhou, Jiaye Liu, Haoyang Ma, Lvhan Fu, Songming Huang, Yue Zhang, Aihua Zhang, Zhanjun Jia
Abstract
Although various stimulator of interferon genes (STING) inhibitors have been identified, no research was performed to investigate the role of human STING inhibitors in AKI. Here, we evaluated the effect of H151 targeting both human and murine STING on cisplatin-induced AKI and observed a protection against renal injury possibly through ameliorating inflammation and mitochondrial dysfunction.
Topics & Concepts
StingAntagonistMedicineAcute kidney injuryCisplatinPharmacologyInternal medicineChemotherapyReceptorEngineeringAerospace engineeringinterferon and immune responsesViral Infections and VectorsViral Infections and Outbreaks Research