TfOH-Catalyzed Cascade C–H/N–H Chemo-/Regioselective Annulation of Indole-2-carboxamides with Benzoquinones for the Construction of Anticancer Tetracyclic Indolo[2,3-<i>c</i>]quinolinones
Lingkai Kong, Wenyue Tian, Zhiyan Liu, Ting Xu, Haoyue Wen, Zihan Chen, Jin Gao, Li‐Ping Bai
Abstract
remarkably suppressed 4T1 xenograft tumor growth without body weight loss.
Topics & Concepts
ChemistryRegioselectivityIndole testAnnulationMoietyAmideStereochemistryCombinatorial chemistryCatalysisOrganic chemistrySynthesis and bioactivity of alkaloidsCatalytic C–H Functionalization MethodsCancer therapeutics and mechanisms